In my 2-Minute Neuroscience videos I simplistically explain neuroscience topics in 2 minutes or less. In this video, I discuss the hypothalamic-pituitary-adrenal, or HPA, axis, which plays an important role in our stress response. I describe the components of the HPA axis (hypothalamus, pituitary gland, adrenal glands) and the hormones released by each of these structures during the stress response.