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miRNA.... miRNA... miRNA... Tumors are bad and we should do something about it. Investigators couldn't get it, now we have to solve it. MiRNA have a solution and don't you guys doubt it. Keep watching and we will tell you all about it Ehhh sexy lady hey hey hey heyyyyyyy sexy lady they present gene expression by transcript degradation They focused on the 3' UTR of a target gene transcript. The transcript must be complimentary to the miRNA seed one stranded integrated into the RISC complex this strand is the guide strand is selected by the AGO protein less stable 5' end and is loaded to the RISC complex and the Antisense is degraded at a RISC complex substrate miRNA start from a double-stranded transcripts Drosha cuts them into one smaller unit in the nucleus they are cleaved from pri to pre then matured in the cytoplasm by Dicer's slicing activity. So now it can do the silencing. They might open up a whole new realm of of cancer therapeutics but there's so much we don't know and so much to discover gene regulation is still so much to discover. Tumors are bad so we should do something about it Investigators couldn't get it now we have to solve it MiRNA have a solution and don't you guys doubt it Ehhhhh sexy lady